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NUITFRANCE - Bibliothèque - Fiche bibliographique
Bibliothèque
Cette rubrique recense :
- de la documentation sur les différents thèmes de la nuit (vie nocturne, pollution lumineuse, pollution sonore, ...).
- les données informatiques relatives à l'éclairage public digitalisées et mises à dispositions en open data par certaines communes,
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Permalien : http://www.nuitfrance.fr/?page=donneesdoc&partie=fiche-bibliographique
Quelques tags associés : [ DOCUMENTATION, PUBLICATIONS, LITTÉRATURE, CONNAISSANCES, LITTÉRATURE GRISE, ARTICLES DE PRESSE, ARTICLES SCIENTIFIQUES, TEXTES JURIDIQUES, PLANS ET PROGRAMMES, JURISPRUDENCE, DÉCRETS, THÈSES ]
► Fiche bibliographique
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Document " Circadian Disruption Accelerates Tumor Growth and Angio/Stromagenesis through a Wnt Signaling Pathway "
Type de document : |
Articles de revue scientifique |
Thème du document : |
Nuit menacée - Lumière artificielle - Impacts métaboliques et physiologiques sur la faune et la flore |
Groupe biologique : |
Mammifères hors humains et chauves-souris |
Auteur(s) : |
YASUNIWA Y. IZUMI H. WANG K.Y. SHIMAJIRI S. SASAGURI Y. KAWAI K. KASAI H. SHIMADA T. MIYAKE K. KASHIWAGI E. HIRANO G. KIDANI A. AKIYAMA M. HAN B. WU Y. IEIRI I. HIGUCHI S. KOHNO K.
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Date de publication : |
Décembre 2010 |
Langue : |
English/Anglais |
Nom du périodique : |
PLOS One |
Précisions : |
Volume 5. Numéro 12, e15330. Pages 1-12 |
Lien contenu/source : |
http://www.plosone.org/article/fetchObject.action?... |
DOI : |
10.1371/journal.pone.0015330 |
Citation courte : |
Yasuniwa et al. (2010) |
Citation complète (format NuitFrance) : |
YASUNIWA Y., IZUMI H., WANG K.Y., SHIMAJIRI S., SASAGURI Y., KAWAI K., KASAI H., SHIMADA T., MIYAKE K., KASHIWAGI E., HIRANO G., KIDANI A., AKIYAMA M., HAN B., WU Y., IEIRI I., HIGUCHI S. & KOHNO K. (2010). Circadian Disruption Accelerates Tumor Growth and Angio/Stromagenesis through a Wnt Signaling Pathway. PLOS One. Volume 5. Numéro 12, e15330. Pages 1-12. |
Résumé du document : |
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Epidemiologic studies show a high incidence of cancer in shift workers, suggesting a possible relationship between circadian rhythms and tumorigenesis. However, the precise molecular mechanism played by circadian rhythms in tumor progression is not known. To identify the possible mechanisms underlying tumor progression related to circadian rhythms, we set up nude mouse xenograft models. HeLa cells were injected in nude mice and nude mice were moved to two different cases, one case is exposed to a 24-hour light cycle (L/L), the other is a more “normal” 12-hour light/dark cycle (L/D). We found a significant increase in tumor volume in the L/L group compared with the L/D group. In addition, tumor microvessels and stroma were strongly increased in L/L mice. Although there was a hypervascularization in L/L tumors, there was no associated increase in the production of vascular endothelial cell growth factor (VEGF). DNA microarray analysis showed enhanced expression of WNT10A, and our subsequent study revealed that WNT10A stimulates the growth of both microvascular endothelial cells and fibroblasts in tumors from light-stressed mice, along with marked increases in angio/stromagenesis. Only the tumor stroma stained positive for WNT10A and WNT10A is also highly expressed in keloid dermal fibroblasts but not in normal dermal fibroblasts indicated that WNT10A may be a novel angio/stromagenic growth factor. These findings suggest that circadian disruption induces the progression of malignant tumors via a Wnt signaling pathway.
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Saisie sur NuitFrance par : |
Rosor |
Saisie sur NuitFrance en : |
Novembre 2014 |
Identifiant NuitFrance : |
NF-BIBLI-193 |
Permalien de la fiche NuitFrance : |
http://www.nuitfrance.fr/?page=donneesdoc&partie=fiche-bibliographique&id_doc=193 |
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