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NUITFRANCE - Bibliothèque - Fiche bibliographique
Bibliothèque
Cette rubrique recense :
- de la documentation sur les différents thèmes de la nuit (vie nocturne, pollution lumineuse, pollution sonore, ...).
- les données informatiques relatives à l'éclairage public digitalisées et mises à dispositions en open data par certaines communes,
Fil d'Ariane : Accueil >> Bibliothèque >> Fiche bibliographique
Permalien : http://www.nuitfrance.fr/?page=donneesdoc&partie=fiche-bibliographique
Quelques tags associés : [ DOCUMENTATION, PUBLICATIONS, LITTÉRATURE, CONNAISSANCES, LITTÉRATURE GRISE, ARTICLES DE PRESSE, ARTICLES SCIENTIFIQUES, TEXTES JURIDIQUES, PLANS ET PROGRAMMES, JURISPRUDENCE, DÉCRETS, THÈSES ]
► Fiche bibliographique
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Document " Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice "
Type de document : |
Articles de revue scientifique |
Thème du document : |
Nuit menacée - Lumière artificielle - Impacts généraux sur la biodiversité |
Groupe biologique : |
Mammifères hors humains et chauves-souris |
Auteur(s) : |
HOGAN M.K.
KOVALYCSIK T.
SUN Q.
RAJAGOPALAN S.
NELSON R.J.
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Date de publication : |
Novembre 2015 |
Langue : |
English/Anglais |
Nom du périodique : |
Behavioural Brain Research |
Précisions : |
Volume 294. Pages 81–88 |
Lien contenu/source : |
http://www.sciencedirect.com/science/article/pii/S... |
DOI : |
10.1016/j.bbr.2015.07.033 |
Mots-clefs : |
Air pollution
Hippocampus
Light pollution
Mood
Particulate matter
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Citation courte : |
Hogan et al. (2015) |
Citation complète (format NuitFrance) : |
HOGAN M.K., KOVALYCSIK T., SUN Q., RAJAGOPALAN S. & NELSON R.J. (2015). Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice. Behavioural Brain Research. Volume 294. Pages 81–88. |
Résumé du document : |
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Air and light pollution contribute to fetal abnormalities, increase prevalence of cancer, metabolic and cardiorespiratory diseases, and central nervous system (CNS) disorders. A component of air pollution, particulate matter, and the phenomenon of dim light at night (dLAN) both result in neuroinflammation, which has been implicated in several CNS disorders. The combinatorial role of these pollutants on health outcomes has not been assessed. Male C3H/HeNHsd mice, with intact melatonin production, were used to model humans exposed to circadian disruption by dLAN and contaminated environmental air. We hypothesized exposure to 2.5 µm of particulate matter (PM2.5) and dLAN (5 lx) combines to upregulate neuroinflammatory cytokine expression and alter hippocampal morphology compared to mice exposed to filtered air (FA) and housed under dark nights (LD). We also hypothesized that exposure to PM2.5 and dLAN provokes anxiety-like and depressive-like responses. For four weeks, four groups of mice were simultaneously exposed to ambient concentrated PM2.5 or FA and/or dLAN or LD. Following exposure, mice underwent several behavioral assays and hippocampi were collected for qPCR and morphological analyses. Our results are generally comparable to previous PM2.5 and dLAN reports conducted on mice and implicate PM2.5 and dLAN as potential factors contributing to depression and anxiety. Short-term exposure to PM2.5 and dLAN upregulated neuroinflammatory cytokines and altered CA1 hippocampal structural changes, as well as provoked depressive-like responses (anhedonia). However, combined, PM2.5 and dLAN exposure did not have additive effects, as hypothesized, suggesting a ceiling effect of neuroinflammation may exist in response to multiple pollutants.
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Saisie sur NuitFrance par : |
Rosor |
Saisie sur NuitFrance en : |
Septembre 2015 |
Identifiant NuitFrance : |
NF-BIBLI-1382 |
Permalien de la fiche NuitFrance : |
http://www.nuitfrance.fr/?page=donneesdoc&partie=fiche-bibliographique&id_doc=1382 |
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